Project Aeterna · by Velogenix Musculoskeletal Intelligence for Women 40+

Strength intelligence
for the weight-loss era.
No hype. Just data.

Most of what you're hearing about GLP-1s and muscle is either fearmongering or pharma optimism. Project Aeterna gives you the actual picture — a research-grounded muscle function tracker built by NIH-funded gerontologists, benchmarked against women your age.

NIH-funded research team Results in 90 seconds Built on 25 years of published research Trusted by coaches, RDs & practitioners On a GLP-1? This matters more →
Project Aeterna
Your Mobility Age
51
🟢 Moves 7 years younger
⬆ High Mobility
Peer comparison78th percentile
⚡ Add plyometric step-ups once weekly. Power — not just strength — is the key driver of long-term mobility and independence.
Section Chief of Endocrinology 200+ peer-reviewed publications Continuous NIH funding — 10+ years Published in Geroscience, JCI Insight, Biochimie
Over Fifty Fitness Members: Start your baseline test today Get full biological analysis for $49 — normally $99 Start Free Test → Use code OFF
Why This Partnership

If you're already active
at 40+, this is built for you.

"Menopause is a muscle event, not just a hormone event. Every woman in our community deserves a real baseline — not guesswork."

PJ Wren · Founder, Over Fifty Fitness · 1,550+ workouts for women 40+

Most women in the Over Fifty Fitness community assume they're "doing fine." The test often reveals hidden deficits in strength, power, or balance — the exact things that determine long-term independence. Knowing your number changes what you train for.

PJ's Over Fifty Fitness community is built around active women who want to push further. Project Aeterna gives those women a real baseline — a Mobility Age score drawn from 25 years of published gerontology research. Together, the data and the programming create something neither delivers alone.

The Challenge Loop
1
Test
Know your Mobility Age. See your peer percentile. Discover what needs work — in 90 seconds.
2
Train
Target your weak points with PJ's 1,550+ workouts — mapped to exactly what your score reveals.
3
Retest
See measurable improvement at the end of the challenge. Your score becomes your accountability.
📊
Velogenix tells you what needs work. Mobility Age, peer percentile, biological gaps — from real NHANES population data. Not a wellness algorithm.
🏋️
Over Fifty Fitness shows you how to fix it. 1,550+ targeted workouts for active women 40+, designed for the menopausal body — not adapted from generic content.
🎯
Exclusive for Over Fifty Fitness members: Get your full biological analysis for $49 — normally $99. Only during the challenge.
What the challenge actually moves
Before challenge
30th
percentile · lower body strength
Mobility age: 61 (actual age: 54)
8 weeks
After challenge
55th
percentile · measurable gain
Mobility age: 52 — 9 years recovered

Illustrative example based on population research · Individual results vary

Exclusive for Over Fifty Fitness members · Muscle Hustle Challenge

See your Mobility Age
in 2 minutes. Free.

Then unlock your full 5-year biological analysis for $49 — normally $99. The offer expires when the challenge ends.

Start Your Baseline Test — Free →
Unlock Premium for $49 — code OFF →
✓ 90 seconds ✓ No equipment ✓ Health data stays on device ✓ 25 years of published research
Or visit Over Fifty Fitness →

"Most women in this programme think they're doing everything right — until they see their Mobility Age."

Not because they're not trying. Because no one has ever given them a real number. The test doesn't judge effort — it measures outcome. That difference is everything.

Find Out Where You Actually Stand →
If This Sounds Familiar

Many women notice something has changed.
Few know how to measure it.

Workouts don't feel as effective as they used to
You feel less powerful, even though your weight hasn't changed much
You've been told to focus on cardio or weight — not function or power
You're worried about staying strong and independent as you get older
You're on a GLP-1 medication and wondering what it's doing to your strength and mobility
No one has ever given you a number that tells you how your body actually performs

Muscle is the organ of longevity.
Project Aeterna gives you the data to understand yours — and act on it.

Take the Free Test →
The Problem

After 40, your body
changes in ways
most tests miss.

Most health platforms track weight, steps, and sleep. None of them measure what actually predicts long-term independence: how strong, stable, and capable your body is in everyday life.

For women 40 and over — whether navigating hormonal change, weight loss on GLP-1 therapy, or simply the biology of aging — muscle function is where the real story is. Strength, balance, and how easily you move decline in ways that often go undetected until the gap is wide. Project Aeterna measures exactly this, benchmarked against women your age using 25 years of published population data.

The good news: these changes are measurable early, and early action makes the biggest difference.

3–8%
Decline in strength and physical capacity per decade after 30. After menopause, falling oestrogen makes it harder to maintain strength and how easily you move — often before your weight changes at all.
Cruz-Jentoft et al. — European Working Group on Muscle Aging, 2019
1 in 5
Women aged 50–64 have used a GLP-1 medication. These treatments are effective for weight loss — but can reduce strength and physical capacity if not paired with targeted resistance training. Knowing where you stand matters.
Wilding et al., NEJM 2021 — GLP-1 and lean mass outcomes
$850
Cost of a professional fitness assessment. Project Aeterna gives you the same insight into your strength and mobility — in 30 seconds, at zero cost.
Rikli & Jones, Journal of Aging and Physical Activity, 1999
GLP-1 & Muscle Health

If you're on a GLP-1,
this matters even more.

GLP-1 medications like Ozempic and Mounjaro are remarkably effective at reducing weight — but the science on muscle is more nuanced than headlines suggest. Most women preserve functional strength. But the picture varies significantly by age, baseline muscle mass, activity level, and whether you're also navigating hormonal change. Knowing which category you're in is the actual question.

📊
Fat loss exceeds muscle loss — but the ratio varies
Most GLP-1 users lose proportionally more fat than muscle. Functional strength is largely preserved. But absolute lean mass does decline — and in lower-muscle, older, or sedentary women, that decline compounds over time.
Cell Reports Medicine, March 2026
⚠️
Protein intake drops when appetite does
GLP-1 medications suppress appetite — which is the point. But reduced appetite often means reduced protein intake at exactly the moment your muscles need it most. Hormonal change compounds this further for women 40+.
Cruz-Jentoft et al., 2019
🎯
Targeted training can protect — but only if you know what to target
Resistance training is the primary evidence-based defence against GLP-1 muscle loss. But "exercise more" is not a plan. Your Mobility Age score tells you exactly which qualities need protecting most.
Hamrick et al., 2024
The Compounding Risk — Without Monitoring
🔴
Muscle aging begins
After 40, hormonal change and natural aging slow muscle protein synthesis. Strength starts declining.
💊
GLP-1 prescribed
Weight loss starts — but appetite drops, protein intake falls, lean mass at risk.
📉
Silent muscle loss
Scale looks good. Body composition quietly worsening. No test, no signal.
🔒
Harder to reverse
Years later, strength and mobility deficits surface — more entrenched, much harder to fix.

A Mobility Age test every 8–12 weeks is the earliest signal that muscle is being protected — or lost.

"The women most at risk are the ones who feel like it's working — because the scale is moving. But if you're losing muscle, not fat, the number that matters is your Mobility Age, not your weight."

Project Aeterna Research Team

Test now to establish your muscle baseline before or during GLP-1 use
Retest every 8–12 weeks to detect early decline — before it's visible
Use Pro's combined HRT + GLP-1 model to see the full picture of what your interventions are doing
Recommended for GLP-1 users
Pro
$149 / year · $12.42/month
HRT + GLP-1 combined modelling — see exactly how both medications are affecting your trajectory
Full 3-test battery — strength, balance, and gait speed for a complete picture
Published physical-function outlook — long-term population reference data on where mobility scores tend to head, drawn from the SWAN menopause-transition cohort study
Composite Mobility Score — a single number that tracks across every retest
Get Pro — $149/year →

✦ Use code OFF for $99/yr during the challenge

Or start with the free test first →
The Research Team

Built by scientists who study
strength and aging in women.

Project Aeterna was built by researchers who have spent careers studying exactly what happens to strength, balance, and physical capacity as women age. The science isn't adapted from general wellness research — it is the research. Every metric, every normative table, every recommendation traces back to peer-reviewed publications from this team or the foundational studies their work builds on.

01 — Lead Researcher
Mark W. Hamrick, PhD
Gerontologist · Musculoskeletal Aging

Distinguished scientist and researcher specialising in the cellular and molecular biology of muscle and bone aging. Research spans muscle aging, longevity interventions, the kynurenine pathway, and sex-specific muscle transcriptomics. Active publications through 2025–2026 in Geroscience, Biochimie, and JCI Insight.

Muscle aging Muscle aging Longevity Exercise metabolism
02 — Medical Lead
Carlos M. Isales, MD
Endocrinologist · Section Chief

Section Chief of Endocrinology, specialising in regenerative medicine, bone health, and the biological mechanisms of healthy aging. Co-investigator on NIH-funded studies of musculoskeletal aging, dietary interventions, and the role of tryptophan metabolism in lifespan extension.

Endocrinology Regenerative medicine Bone health NIH-funded
03 — Research Team
Sadanand Fulzele, PhD
Cell Biology · Musculoskeletal Aging

Expert in cellular biology of musculoskeletal aging. Co-author on studies of lipid metabolism in muscle and bone aging, COVID-19-related muscle loss, and microbiota-derived compounds that extend lifespan and improve muscle and bone health. Publications active through 2026.

Cell biology Osteoporosis Lifespan extension Microbiome
Verified Research Record
25 publications on PubMed — including work published in 2025 and 2026.

Topics include muscle aging, longevity interventions, tryptophan and kynurenine metabolism in aging muscle, sex-specific muscle transcriptomics, lipid metabolism in age-related musculoskeletal disorders, and microbiota-derived compounds that improve muscle and bone health. Continuously NIH-funded for over a decade.

View on PubMed →
After Your Test, You'll Get

Real information about
your body — not population averages.

📊
Your mobility age
How your body is functioning compared to women your age — in a number you can actually use.
👥
Your peer percentile
Where you stand compared to age-matched women — drawn from real NHANES population data, not estimates.
One specific action
A single evidence-based recommendation tailored to your score — not generic advice, but a concrete next step.
Take the Free Test →

No signup · No equipment · 90 seconds

The Technology

A model that estimates
how your inputs relate
to biological aging.

Most longevity apps treat all women the same. Project Aeterna Premium takes a different approach — it estimates how your specific hormonal profile, interventions, and inputs relate to strength and mobility, using a neural network trained on published intervention research. It's a model estimate personalised to your inputs, not a clinically validated prediction.

The model estimates how your strength and mobility may change over the next 3–5 years — and what you can do to influence the outcome. Tell it what you're already doing (HRT, GLP-1, resistance training, supplements) and it shows you how that changes the estimate.

No other consumer health app models this. It exists because the research team that built it has spent decades studying exactly these mechanisms.

50+ lifestyle factors modelled
GLP-1 medications, hormone therapy, creatine, resistance training, protein intake, sleep quality — and how they interact in your body after menopause.
Personalised to your inputs
The model accounts for the specific changes menopause causes — including inflammation, energy production, and how your body responds to exercise — across pre-, peri-, and post-menopause.
Hormonal context built in
Most longevity tools treat all women the same. This model doesn't. It accounts for your specific hormonal profile — pre-, peri-, post-, and surgical menopause, plus HRT route — because the biology is genuinely different.
Unlock GNN Modelling — Premium $99 →
The Test

Three steps.
Ninety seconds.
Research-backed data.

01
📋
Your profile

Age, height, weight, and menopause stage. Four questions that personalise your score against age-matched peers drawn from NHANES population data.

Processed on your device. Never transmitted or stored.

02
🪑
The test

Stand up from a chair fully, sit back down — as many times as you can in 30 seconds. Tap the screen to count each stand. No equipment needed.

Rikli & Jones (1999) 30-second chair stand protocol.

03
📊
Your results

Your mobility age. Your peer percentile. One clear action to take next. Data that previously required specialist equipment — in under two minutes.

Premium adds biological age modelling and 5-year trajectory.

🔬

Simple, research-grounded input. Hold your phone and tap +1 each time you stand — matching the original observer-count method from the Rikli & Jones validation. This tap-based rep count is the same count used in NHANES normative comparisons.

What's Included

Start free.
Go deeper when ready.

The free test gives you real, useful data. Premium and Pro are annual plans — no monthly billing, no recurring surprises.

🎯
Muscle Hustle Challenge exclusive — $50 off Premium or Pro. Enter code OFF at checkout. Premium drops to $49/yr · Pro drops to $99/yr.
OFF
Standard
Free — always
  • 30-second sit-to-stand test
  • Mobility age estimate
  • Peer percentile — NHANES norms
  • 1 personalised action to take next
  • Tap-to-count sit-to-stand test
  • No signup. Health data stays on device.
Try Free Now →
Best Value
Pro
$149 / year
  • Everything in Premium
  • Full 3-test battery
  • One-leg timed balance (both legs)
  • Gait speed assessment
  • Composite Mobility Score
  • Published physical-function outlook
  • HRT + GLP-1 combined modelling
Get Pro — $149 →

✦ Use code OFF for $99/yr

What Premium Shows You

Not a score.
A 5-year picture
of your muscle future.

The free test tells you where you are today. Premium shows you where you're headed — and what changes your trajectory.

Input what you're already doing — HRT, GLP-1, creatine, resistance training — and watch your 5-year forecast update in real time. This is the conversation your doctor should be having with you.

Unlock Premium — $99/year →

Annual plan · Cancel anytime · $8.25/month

Premium Report · Sample
Sarah, 54 · Post-menopause
Updated today
Mobility Age
47
7 yrs younger than peers
Biological Age
49.3
GNN model estimate
5-Year Mobility Trajectory
Now Year 3 Year 5 With your changes Without
Active Interventions
✓ HRT ✓ Resistance training 3×/wk ✓ Creatine 5g/day + Add GLP-1
Coach PJ · Top recommendation
Add plyometric step-ups once weekly. Power — not just strength — is the primary driver of your 5-year trajectory gap. Based on what you're already doing, this single change shifts your Year-5 forecast by 1.8 mobility years.
After Your Free Test

Your score is step one.
The trajectory is what changes everything.

Most women take the free test, see their number — and then want to know: is it going to get worse? Premium answers that. It shows where your strength and mobility are headed over 5 years, and tells you exactly which one change would make the biggest difference.

Take the free test
Get your mobility age, peer percentile, and one clear action to take next. Free, always.
See your trajectory
Premium maps where your score is headed across 5 years — and what changes it.
Change the outcome
Coach PJ tells you the single most effective thing to do next for your profile.
Upgrade to Premium — $99/year →

$8.25/month · Cancel anytime · Built on published research

01 — Rikli & Jones, 1999
30-Second Chair Stand Test — the research foundation

Published in the Journal of Aging and Physical Activity. Established normative data and test-retest reliability for the STS protocol. This is the study your score is built on.

02 — NHANES Population Data
Age-matched peer comparison, not modelled estimates

Your percentile is drawn from the National Health and Nutrition Examination Survey — real population data from real women your age, stratified by BMI and menopause stage.

03 — Hamrick et al., ongoing 2025–2026
Tryptophan, kynurenine & longevity interventions in aging muscle

The team's most recent work — published in Biochimie and Geroscience — directly informs the intervention recommendations and the GNN biological age model used in Premium.

04 — Hallmarks of Aging Research
GNN biological age modelling (Premium)

The Premium model is trained across 12 hallmarks of aging including mitochondrial function, cellular senescence, and inflammation — personalised to your intervention profile and menopause stage.

05 — SWAN Study of Women's Health Across the Nation
Menopause-stage decline rates & the Pro physical-function outlook

A 20+ year longitudinal cohort tracking women through the menopause transition. Greendale et al. (2019, JCI Insight) grounds how the model weights strength and lean-mass change by menopause stage; Solomon et al. (2022, JAMA Network Open) is the published 10-year cohort data behind Pro's physical-function outlook.

The Evidence Base

Not adapted from
wellness research.
Built for women's aging.

The sit-to-stand test has been a standard tool in gerontology for 25 years. It measures lower body strength and power — and correlates strongly with long-term independence, mobility, and quality of life. It has been validated across multiple studies, referenced in NHANES normative data, and used in research worldwide.

Research is increasingly clear that muscle function declines in ways that often go undetected — accelerated by hormonal change, weight loss interventions, and the natural biology of aging after 40. The sit-to-stand protocol captures this directly. When the app recommends a specific action, that recommendation traces back to peer-reviewed evidence — not a wellness algorithm.

This is where SWAN — the 20+ year Study of Women's Health Across the Nation — matters: it's the specific longitudinal evidence the model draws on for how strength and lean mass change through the menopause transition, not just general aging research.

The tap-to-count input method is actually closer to the original Rikli & Jones observer-count methodology than an automated sensor would be. The rep count is the rep count. The NHANES normative tables don't care how it was recorded.

Take the Free Test →
🔒
Privacy
Your health data never leaves your device.

All test processing happens locally on your phone. Sit-to-stand data is analysed in real time and not stored. We never collect your health data, location, or any biometric information. No account or email required to take the test.

Health data stays on device Email used only for results No sit-to-stand data stored No third-party data sharing
Evidence-Based Nutrition

The supplements
your score may actually need.

Your Mobility Age reveals where you're losing ground. The science is clear on two inputs that directly support muscle function — and both are chronically under-consumed by women after 40.

We partnered with Momentous because their products are third-party tested, NSF Certified for Sport, and built on the same peer-reviewed research base we use at Velogenix. Momentous’s women’s supplement line was developed in collaboration with Dr. Stacy Sims, whose research on female physiology and GLP-1 interactions directly informs our GNN model — and whose Collective X Health partnership with Momentous is actively funding new female performance research that underpins these recommendations.

NSF Certified for Sport Third-Party Tested Informed Sport Certified
Why these two? The research.
CR
Creatine Monohydrate
Post-menopausal women show accelerated phosphocreatine depletion. Supplementation supports muscle power output, strength gains from resistance training, and — emerging data suggests — bone density preservation.
PR
Protein
Anabolic resistance increases after menopause — meaning you need more dietary protein to achieve the same muscle-building signal. Most women over 50 consume significantly less than the evidence-based recommendation of 1.6–2.0 g per kg bodyweight.
Primary Recommendation
Momentous Creatine
Creapure® monohydrate — the most studied form. 5g daily is the evidence-based dose for muscle function and power output. Flavorless, mixes cleanly.
  • Supports strength gains from resistance training
  • May help preserve lean mass during caloric restriction (GLP-1 users)
  • Emerging bone health data in post-menopausal women
  • Creapure® certified — purest available source

Recommended for women whose Mobility Age score shows a power or strength deficit.

Get Your Score First →Then Shop Creatine at Momentous →

Affiliate link — we may earn a small commission. This doesn't affect our recommendations.

For Active Women
Momentous Protein
Whey isolate and plant-based options available. High leucine content to maximise the muscle protein synthesis response — especially important when anabolic resistance is elevated post-menopause.
  • High-leucine formula to overcome anabolic resistance
  • Supports lean mass retention alongside resistance training
  • Critical for GLP-1 users managing muscle vs. fat loss
  • NSF Certified — batch-tested for banned substances

Recommended for women whose score indicates reduced lean mass or low protein adequacy.

Get Your Score First →Then Shop Protein at Momentous →

Affiliate link — we may earn a small commission. This doesn't affect our recommendations.

💡
Why we recommend these — not a general supplement list. Project Aeterna measures the things creatine and protein directly support: muscle strength, power, and balance. If your score reveals a deficit, these two inputs have the most direct evidence behind them for women 40 and over navigating weight loss, hormonal change, or healthy aging. We recommend nothing we wouldn't take ourselves.
What The Evidence Actually Shows

Most women on GLP-1s
preserve their functional strength.
But not everyone does.

What the research says
  • Fat mass reduces more than lean mass on GLP-1 therapy — the ratio is favourable for most users
  • Functional strength is largely preserved — and in some cases improves relative to body weight
  • Muscle quality — mitochondrial efficiency, reduced intramuscular fat — can actually improve
  • The nuance the headlines miss: at-risk subgroups — older, sedentary, low baseline muscle — face genuinely different outcomes
What knowing your number gives you
  • Know whether you're in the protected majority — or a subgroup that warrants closer attention
  • Track your functional strength over time — not just the number on the scale
  • Get specific, evidence-based actions — resistance training, protein targets, supplement priorities
  • Walk into any health conversation with a real functional baseline, not a guess
The question isn't whether GLP-1s are safe. It's whether you specifically are staying strong. That's a measurable number.
Get Your Score — Free →
For Practitioners

The musculoskeletal intelligence layer your clients don't have.

If you're an RD, personal trainer, or clinician working with women on GLP-1 therapy, menopause, or healthy aging — your clients are asking questions you can't fully answer without a functional baseline. Project Aeterna gives you that baseline, grounded in the same NHANES and DrugBank data used in published research.

You provide the trust and the programming. We provide the musculoskeletal intelligence. Neither of us can do the other's job — and that's the point.

Talk to Us About Practitioner Access →
Client Assessment
Send clients a baseline link
A 90-second mobility assessment benchmarked against NHANES age, BMI, menopause stage, and ethnicity norms. Results you can discuss in the next session.
GNN Modelling
Model interventions before prescribing them
See how a client's combination of HRT, GLP-1 therapy, exercise, and supplementation is predicted to affect their 12 biological aging hallmarks — grounded in DrugBank and GenAge.
Coming Soon
Practitioner dashboard & API
Track clients over time, view aggregate trends across your practice, and integrate Velogenix data into your existing workflow. Reach out to join the early access list.
Common Questions

What people ask
before they test.

What is the best app for tracking muscle loss on GLP-1? +
Project Aeterna is the only home-based platform that combines a validated 30-second Sit-to-Stand mobility test with a Graph Neural Network biological age model to track muscle function specifically for women on GLP-1 therapy. Unlike apps that track weight or injection schedules, Aeterna tracks actual muscle function benchmarked against age-matched peers using 25 years of NHANES population data.
Does Momentous creatine help with muscle loss on Ozempic? +
Creatine monohydrate supports resistance training outcomes and may help preserve lean mass during caloric restriction on GLP-1 therapy — but it works as a multiplier on training stimulus, not a standalone intervention. Women on Ozempic or Wegovy who combine Momentous Creatine with resistance training and adequate protein intake show better lean mass retention than those relying on medication alone. Tracking whether it is working requires a functional muscle baseline — which the Project Aeterna 30-second STS test provides monthly.
How do I know if I’m losing muscle on Ozempic or Wegovy? +
The most practical home method is the validated 30-second Sit-to-Stand test, built on 25 years of NHANES population data. Project Aeterna uses a simple tap-to-count version of this test and benchmarks your result against age-matched peers, generating a Mobility Age score you can track monthly. A declining score is a signal to act — adjusting your protein intake, resistance training, or supplement routine — before the gap widens.
Is there an app that tracks muscle health and aging for women? +
Project Aeterna tracks functional muscle age using a Graph Neural Network biological age model trained on NIH-funded gerontology data, benchmarked against NHANES norms stratified by age, BMI, menopause stage, and ethnicity. It is the only wellness platform to combine a validated mobility test with GNN-based biological age modelling, designed specifically for women 40 and over navigating GLP-1 therapy, perimenopause, or healthy aging.
What is Project Aeterna? +
A free 30-second home mobility test built by NIH-funded gerontologists that measures your Mobility Age and compares it against age-matched peers using NHANES population data.
Who is Project Aeterna designed for? +
Women 40 and over who want to understand their actual muscle function — whether they’re navigating weight loss on GLP-1 therapy, the hormonal changes of perimenopause and beyond, or simply want a data-driven baseline for healthy aging.
Is my health data private? +
Yes. All test processing happens locally on your device. Sit-to-stand data is analysed in real time and not stored. Your health data never leaves your phone. No account or email is required to take the test.
Get Started Today

Your body is telling you
something. Now you can measure it.

90 seconds, a chair, and your phone. Get your mobility age, your peer percentile, and one evidence-based action — emailed to you instantly.

Get Your Free Score → Explore Premium — $99

Takes 90 seconds · No equipment · 25 years of published research

Get In Touch

Questions about the research,
the app, or your results?

We're researchers first. If you have questions about the science behind your score, want to report a bug, or are interested in partnering with Velogenix — we'd like to hear from you.

✉  Email Us →