One challenge facing us as we age is to maintain our normal activities of daily living.  Velogenix seeks to develop novel interventions and technologies that promote healthspan, or the length of time an individual is active and engaged.  We focus especially on improving muscle and bone health in older adults to support healthy aging .

Our team of clinicians and scientists works to identify novel mechanisms involved in the aging of muscle (sarcopenia) and bone (osteoporosis).  We tailor our therapeutic interventions to target these cellular and molecular mechanisms.  Importantly, many of these age-related pathways differ between men and women, and so we prioritize a sex-specific approach for improving healthspan.

We currently have several lead molecules in our development pipeline targeting the kynurenine pathway, a key pathway involved in muscle and bone loss with aging.  Accumulation of kynurenine, a metabolite of the amino acid tryptophan, with aging is now linked with a number of age-associated disorders.  Our pipeline includes molecules for the prevention of both  osteoporosis and sarcopenia.